Objective: To explore the effects of remifentanil (REM) combined with low-dose sufentanil (SUF) on hemodynamics and postoperative anesthesia recovery in interventional surgery for congenital heart disease in children. Methods: A total of 64 children undergoing closure of atrial septal defect and ventricular septal defect in the 81st Army Hospital from Jan. 2019 to Jan. 2021 were extracted to be randomly divided into the observation group and the control group

with 32 cases in each group. The control group was treated with REM for anesthesia

while the observation group was additionally given low-dose SUF for anesthesia based on the control group. The hemodynamics indicators such as mean arterial pressure (MAP)

heart rate (HR)

systolic blood pressure (SBP)

diastolic blood pressure (DBP) before anesthesia induction (T1)

after anesthesia induction (T2)

after tracheal intubation (T3)

after sternum incision (T4) and after closure opening (T5) were observed. Procalcitonin (PCT)

C-reactive protein (CRP) and cortisol (Cor) before and after surgery in both groups were detected. The surgery time

anesthesia time

recovery time of postoperative respiratory

extubation time

scores of crying

requires increased oxygen administration

increased vital signs

expression and sleeplessness (CRIES)

and the incidence of postoperative complications such as respiratory depression

nausea

vomiting and emergence agitation in both groups were recorded. Results: There was no significant difference in hemodynamics indicators between two groups at T1

T2

T3

T4 and T5 (P>0.05). After surgery

the serum levels of PCT

CRP and Cor in the observation group were significantly lower than those in the control group (P<0.05). The difference in surgery time and anesthesia time between two groups was not statistically significant (P>0.05)

yet the recovery time of postoperative respiratory and extubation time in the observation group were shorter than those in the control group (P<0.05). The total score of CRIES in the observation group was lower than that in the control group (P<0.05). The incidence of postoperative complications in the observation group was lower than that in the control group (P<0.05). Conclusion: REM combined with low-dose SUF for intervention anesthesia of children with congenital heart disease can effectively maintain the stability of intraoperative hemodynamics

shorten the recovery time of postoperative respiratory

reduce the intraoperative stress response and effectively decrease the incidence of postoperative complications.